Integrated by the Parish of San Juan Bautista, patron saint of the city and the Diocesan Sanctuary of Our Lady of Guadalupe, formerly Temple of the Natives and Parish of the Spaniards, respectively. Built in the eighteenth century, at the same point on which the first chapel was founded in 1531, according to the stories of the foundation of San Juan del Río. It is the main religious center in the city.

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